Shire plc has acquired Lumena Pharmaceuticals, Inc., a biopharmaceutical company with late stage rare disease assets, for an upfront payment of $260 million in cash, plus a payment for cash at closing and near-term milestones related to ongoing clinical trials.   The acquisition expands Shire’s gastrointestinal portfolio, as well as liver disease, with LUM001, in Phase II development with four potential orphan indications, and LUM002 for the treatment of non-alcoholic steatohepatitis (NASH...